Maternal age and origin of non-disjunction in trisomy 21.
نویسندگان
چکیده
The role of maternal age in chromosomal non-disjunction was investigated by studying 51 families in whom the origin of the meiotic anomaly had been identified. Results of this study were compared with previously published data. This comparison did not show any difference in mean maternal age, nor in distribution of maternal ages when the origin of non-disjunction was maternal, or paternal, or occurred at the first or second meiotic division. These results make questionable the role of maternal age in the birth of Down's syndrome children.
منابع مشابه
Origin and mechanisms of non-disjunction in human autosomal trisomies.
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INTRODUCTION Free trisomy 21 is responsible for 95% of Down syndrome cases. Advanced maternal age and susceptible recombination patterns are recognized risk factors associated to Down syndrome. Maternal origin of trisomy occurs in approximately 90% of cases; paternal and mitotic origin share the remaining 10%. However, the recombination events that serve as a risk factors for trisomy 21 have no...
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عنوان ژورنال:
- Journal of medical genetics
دوره 17 5 شماره
صفحات -
تاریخ انتشار 1980